Publications

Below is a list of selected scientific publications arising from our laboratory. Click on either David Long, Paul Winyard or Rukshana Shroff for more!

"Systemic gene therapy with thymosin β4 alleviates glomerular injury in mice"

We found that treating mice with a protein called thymosin beta 4 by gene therapy protects podocytes in a model of glomerular injury by protection of the podocyte cytoskeleton.

"Lithium induces mesenchymal-epithelial differentiation during human kidney development by activation of the Wnt signalling system."

We found that addition of lithium encourages the production of nephrons from human embryonic kidney cells

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"Vangl2, a planar cell polarity molecule, is implicated in irreversible and reversible kidney glomerular injury"

We found that a protein that is normally involved in instructing cells how to orientate themselves, called Vangl2, is has a role in protecting podocytes in the kidney from damage in renal disease in mice

"Spatiotemporal dynamics and heterogeneity of renal lymphatics in mammalian development and cystic kidney disease"

We used 3D imaging techniques and computerised analysis to find out how lymphatics grow during normal kidney development and what goes wrong in polycystic kidney disease

"Vascular endothelial growth factor C (VEGF-C) for polycystic kidney diseases"

We found that VEGF-C, a protein which normally helps blood vessels and lymphatics to grow, helps to reduce the severity of disease and improve renal function in mouse models of polycystic kidney disease

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"Pseudouridylation defect due to DKC1 and NOP10 mutations cause nephrotic syndrome with cataracts, hearing impairment and enterocolitis"

We identified a new kind of kidney disease in humans which occurs due to faulty modifications to messengers of the cell: RNA